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MYP_021739
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Basic Information
WV (De Novo Synthesis)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C68H106N18O14
Standard
Sequence
WVKAAAKAAAKVW
Physicochemical Analysis
1399.68 Da
10.30
2.76
2.55
0.2121
0.44
0.56
0.23
-6.05
90.77
0.1538
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
522.16
-1.52
19.0
17.0
43.0
100.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001580 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus ATCC 27853
128 μM
MIC
PaperSymmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency PMID30897850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30897850/
RECORD: Rec_0006536 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium ATCC 14028
128 μM
MIC
PMID30897850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30897850/
RECORD: Rec_0022152 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus faecalis ATCC 29212
64 μM
MIC
PaperSymmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency PMID30897850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30897850/
RECORD: Rec_0036321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Human RBC
256 μM
Hemolysis
PMID30897850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30897850/
RECORD: Rec_0054978 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
HEK293T cells
PaperSymmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency PMID30897850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30897850/
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