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MYP_021734
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Basic Information
Maculatin 1.2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
23 amino acids
C109H167N31O29
Standard
Sequence
GLFVGLAKVAAHNNPAIAEHFQA
Physicochemical Analysis
2375.68 Da
6.92
-0.06
-0.37
-0.0028
0.44
0.34
0.32
8.12
102.17
0.0870
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.68
-8.17
30.0
31.0
74.0
169.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0193569 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50 μg/mL
MIC
PMID9620615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0201357 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus uberis
6 μg/mL
MIC
PMID9620615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0214250 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
RECORD: Rec_0243781 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
Staphylococcus epidermidis
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
RECORD: Rec_0269339 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata,Litoria eucnemis [Animal]
Maculatin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
PaperCancerPPD2 curated year-page record (1996–2000); partial row recovered from visible page.
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