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MYP_021734
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Basic Information
Maculatin 1.2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
23 amino acids
C109H167N31O29
Standard
Sequence
GLFVGLAKVAAHNNPAIAEHFQA
Physicochemical Analysis
2375.68 Da
6.92
-0.06
-0.37
-0.0028
0.44
0.34
0.32
8.12
102.17
0.0870
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.68
-8.17
30.0
31.0
74.0
169.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165611 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0173543 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.7%, E 0.0%, T 56.5%, C 21.7% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0178050 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID9620615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0184542 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
Listeria innocua
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
RECORD: Rec_0188667 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
S.faecalis
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
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