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MYP_021734
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Basic Information
Maculatin 1.2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
23 amino acids
C109H167N31O29
Standard
Sequence
GLFVGLAKVAAHNNPAIAEHFQA
Physicochemical Analysis
2375.68 Da
6.92
-0.06
-0.37
-0.0028
0.44
0.34
0.32
8.12
102.17
0.0870
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.68
-8.17
30.0
31.0
74.0
169.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017300 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
Micrococcus luteus
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
RECORD: Rec_0021895 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Litoria genimaculate, Litoria eucnemis, Australia
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
PMID9620615;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0040181 VERIFIED: NO
Provenance & Taxonomy
Fringed tree [Animal]
Maculatin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0053456 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0117463 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculate [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Streptococcus uberis is recognized around the world as the problem mastitis bug. This peptide appears to be particularly effective in eliminating this bug. Chemical modification: C-terminal NH2. A=26%
Bio-Activity Profile
Antimicrobial Anticancer
Bacillus cereus
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
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