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MYP_021718
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Basic Information
NRC-12
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C135H208N38O31
Standard
Sequence
GWKKWFNRAKKVGKTVGGLAVDHYL
Physicochemical Analysis
2859.33 Da
10.30
4.84
4.58
0.1937
-0.52
0.72
-0.02
17.45
74.00
0.1600
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1134.83
-7.10
41.0
37.0
95.0
204.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001920 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0002549 VERIFIED: YES
Provenance & Taxonomy
American plaice [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli DC2
2 μM
MIC
PaperNovel antimicrobial peptides derived from flatfish genes PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0009936 VERIFIED: YES
Provenance & Taxonomy
American plaice [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antifungal
A. salmonicida 99-1
2 μM
MIC
PaperNovel antimicrobial peptides derived from flatfish genes PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0038474 VERIFIED: YES
Provenance & Taxonomy
Hippoglossoides platessoides [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa Z61
1 μg/mL
MIC
PaperPatenting computer-designed peptides. Journal of Computer-Aided Molecular Design, 12: 543-556 Evidence URLhttps://camp3.bicnirrh.res.in/seqDisp.php?id=CAMPSQ2884
RECORD: Rec_0073305 VERIFIED: YES
Provenance & Taxonomy
American plaice [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antifungal
A. salmonicida 97-4
2 μM
MIC
PaperNovel antimicrobial peptides derived from flatfish genes PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
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