Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2340H3776N594O677S21

DescriptionStandard

        MFLPHCLVLLSLITTTFSINPGVKVELTEKGLEYGRQLAIASIQQKLKSIKVPDMSGKERISPIGKVQYSLTNMHIVNAGLPKSAVDLVPGTGVRLSITNAFITMNGRWRVKYLRIIKDSGSFDLSVNGLSISTSIAISSDETGRPMVSSVNCAANVGEVTIKFHGGASWLYNLFRKYIEKALRGAMEKQICPLVTDAVSDLNIRLKTLNVLAKVDEYAEIEYSMVSSPTISNSAIVLNLKGEFYNIGKHQEPPFSATTFSMQSQTNNMLSVGISAFTANSAAFVYNAAGMLSLYITDDMIPKSSLFHLNTKSFSVFIPQLEKQFPNMTMKLLVKTVKNPVITFEPDNATIQALCSVTAYAIQPNATLSPLFVLNLESSVSARVFVSGMKLAGEITLNEMNLTLATSYVGEFKVKSLDNIFQMVLKVVILPKLNALLAKGYPLPTIEAMKLENTKLLVLKDFVLIGTDVQFIG
    

Molecular Weight51735.95 Da

Isoelectric Point (pI)9.15

Net Charge (pH 7.0)8.93

Net Charge (pH 7.4) 8.28

Charge Density (pH 7.0) 0.0189

GRAVY Index0.24

Hydrophobic Moment 0.81

Boman Index0.17

Instability Index28.15

Aliphatic Index 106.53

Aromaticity 0.0782

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287278 VERIFIED: NO

Provenance & Taxonomy

OrganismGouania willdenowi [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence