Peptide Database

Peptide NameSC20EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC123H189N27O37

DescriptionStandard

        WEEWDKKIEEYTKKIEELIK
    

Molecular Weight2637.98 Da

Isoelectric Point (pI)4.82

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.1114

GRAVY Index-1.52

Hydrophobic Moment 0.67

Boman Index-0.29

Instability Index73.60

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1079.46

LogP -3.12

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 94.0

Heavy Atoms 187.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0330218 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity0.2024±0.0054 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0407628 VERIFIED: YES