Peptide Database

Peptide NameSLAY-screened peptide P3495

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC92H158N34O25S

DescriptionStandard

        VGSAICARARRTAVPHAVSHL
    

Molecular Weight2172.52 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)2.90

Net Charge (pH 7.4) 2.57

Charge Density (pH 7.0) 0.1380

GRAVY Index0.39

Hydrophobic Moment 0.44

Boman Index0.04

Instability Index41.93

Aliphatic Index 102.38

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.28

LogP -11.59

H-bond Donors 36.0

H-bond Acceptors 31.0

Rotatable Bonds 67.0

Heavy Atoms 152.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0095983 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/