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MYP_021618
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Tubulin-Tyrosine Ligase Inhibitor
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
2 amino acids
C12H16N2O4
Standard
Sequence
AY
Physicochemical Analysis
252.27 Da
5.57
-0.21
-0.39
-0.1026
0.25
0.31
0.44
5.00
50.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
-0.15
4.0
4.0
5.0
18.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150238 VERIFIED: YES
Provenance & Taxonomy
Glycine max [Plant]
ACE-inhibitory peptide
3847
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
48 μg/mL
IC50
PaperAntihypertensive effect of peptide-enriched soy sauce-like seasoning and identification of its angiotensin I-converting enzyme inhibitory substances PMID19994857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19994857/
RECORD: Rec_0159800 VERIFIED: NO
Provenance & Taxonomy
Zea mays [Plant]
ACE-inhibitory peptide
4577
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
14.2 μM
IC50
PaperISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS. PMID24915368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24915368/
RECORD: Rec_0176466 VERIFIED: YES
Provenance & Taxonomy
Fagopyrum tataricum [Plant],Zea mays [Plant],Triticum aestivum [Plant],Amaranthus hypochondriacus [Plant],Oryza sativa [Plant],Glycine max [Plant]
ACE inhibitory peptide
4577;4565;28502;4530;3847
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory Antihypertensive
ace
10-1100 μg/mL
IC50
PaperBioactive peptides in amaranth (Amaranthus hypochondriacus) seed | Vegetable foods: a cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities | Isolation and characterization of peptides with antihypertensive activity in foodstuffs | Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity | PubMed PMID 17715987 | PubMed PMID 19994857 | PubMed PMID 12093003 PMID17715987;19994857;12093003 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17715987/
RECORD: Rec_0183638 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
20000 μM
IC50
PaperStructural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides. PMID16448176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16448176/
RECORD: Rec_0216497 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
40 μM
IC50
Rat plasma, in vitro; 564 s
PMID14980787 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14980787/
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