Peptide Database

Peptide NameCurvacin A / sakacin A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC187H281N53O56S3

DescriptionStandard

        RSYGNGVYCNNSKCWVNWGEAKENIAGIVISGWASGLAGM
    

Molecular Weight4263.75 Da

Isoelectric Point (pI)8.02

Net Charge (pH 7.0)0.74

Net Charge (pH 7.4) 0.50

Charge Density (pH 7.0) 0.0185

GRAVY Index-0.10

Hydrophobic Moment 0.36

Boman Index0.17

Instability Index13.64

Aliphatic Index 70.75

Aromaticity 0.1250

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1770.96

LogP -19.76

H-bond Donors 64.0

H-bond Acceptors 60.0

Rotatable Bonds 137.0

Heavy Atoms 299.0

Ring Count 8.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0346826 VERIFIED: YES

Provenance & Taxonomy

OrganismEnterococcus faecium [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)