Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2156H3489N555O616S21

DescriptionStandard

        MMFLCCWLALVALIPTTVSINPGVKVKLTEKGLEYGRDLGMATIQQKLKTIKVPDMSGEQRVSPIGKVHYSLTNMHIVNVGLPKSAVDLVPGTGVRLSITNAFISLQGNWRVKYLRIIKDSGSFDLNVNGLTITSSIAIKSDETGRPAVSSVNCAATVSKKPCCALRLNPHVGEWNVILAKVDPYAEIEYSMVSSPTVSKSSIDFSLKGEFYNIGKHQEPPFSPKPFTLAPQINNMLYIGVSAFTTNSAAFVYNKAGALSLAITDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVKTVKDPIITFETNNMTVQAIGTVTAYAIQPNATLSPLFVLNMDTSVSARVYVSGVKLAGAVTLNKMDLTLGTSYVGDFQVGSLDNILQMVLKVVVIPKLNVQLAKGYPLPTLGKMKLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight47714.48 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)14.80

Net Charge (pH 7.4) 14.22

Charge Density (pH 7.0) 0.0336

GRAVY Index0.22

Hydrophobic Moment 0.65

Boman Index0.16

Instability Index31.87

Aliphatic Index 103.84

Aromaticity 0.0727

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216937 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence