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MYP_021552
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Basic Information
Interferon-induced protein with tetratricopeptide repeats 3
Antiviral
Immunology ▸ Immunomodulation ▸ Innate immune effector
Immunology ▸ Immunomodulation ▸ Innate immune signaling adaptor
Regulatory peptide ▸ Biological modulation
Standard
490 amino acids
C2456H3838N670O785S21
Standard
Sequence
MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
Physicochemical Analysis
55984.13 Da
5.12
-19.64
-20.76
-0.0401
-0.74
0.88
-0.11
47.01
75.49
0.0857
61770.00
62520.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013137 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IFIT
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Innate immune effector Interferon pathway modulator
Virus titer assay in Daudi cells
PaperIdentification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene PMID20686046 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20686046/
RECORD: Rec_0041682 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IFIT
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Innate immune signaling adaptor RNA-sensing effector
RNA viruses
PaperIFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1 PMID21813773 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21813773/
RECORD: Rec_0278103 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IFIT
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral RNA-sensing effector Interferon pathway modulator
5'-triphosphate RNA viruses
PaperIFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA PMID21642987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21642987/