Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2436H3851N639O682S22

DescriptionStandard

        TREDMARGPCNAPRWASLLVLVVVGTAVAAAINPGVVVRISQKGLDYATQQGTAALQKELERIKIPDYSGSFKIKLLGKGHYSFYSMDIREFQLPSAQIRMVPNVGLKFSISNANIKISGKWKARKSFLKTSGEFDLSIGGMSISADLMLGSNLTSGKPTVTCASCSSHISSVHVHISNSKVGWLIQLFHKKIESALRNKLNSQVCQKVTSSVSSELQPYFQTLPVMTKIDAVAGIDYGLVAPPTITAETLDAQMKGEFYRLNHHNPPPFAPPVMEFPAVHDHMVYLGLSDYFFNTAGLVYQEAGVLKMTLTDDMIPKESRFRLTTKFFGSFLPEVAKMFPNMKMQIHISASVPPQLSVQPTGLTFFPALDIQAFAVLANSSLASLFLIGMSTHGSLEVSARSDRLVGELNVDRLLLELKHSTIGPFPVELLQDIMNYIVPTLVLPRVNERLQKGFPLPMPARVQFYNMVLQPHQNFLLFGADVVYK
    

Molecular Weight53706.94 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)10.52

Net Charge (pH 7.4) 9.51

Charge Density (pH 7.0) 0.0216

GRAVY Index0.09

Hydrophobic Moment 0.70

Boman Index0.13

Instability Index40.25

Aliphatic Index 95.87

Aromaticity 0.0883

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0236616 VERIFIED: NO

Provenance & Taxonomy

OrganismCebus imitator [Animal]

FamilyBPI/LBP

Tax ID9516

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria