Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length396 amino acids

Chemical FormulaC1975H3142N524O560S14

DescriptionStandard

        MRLILPLIFSQLVSGTKQEEPGVKGCLTLKGLNYGKRMAPNYKTNVSFILSLPRIQIKKLDLSDSKAVYVPNNGTNLLVSNGQILITGSIFTNLEVFASGLSFTGKLGVTSDDKGHGKIWNEGCSSNVDDVEISFHGGWRKVDSVSSLEYQLVDLPQIKEQSLDLLVKGQFIGHSQRWDFPGQPVNLVLPEADSHMVLLALSEFSANSAGYVHFMSGILSYNVTDNIVSAGVRYIITYSCFFPSVFCLQITTQFPDSPTLLLHVWAHSPPAVTCQPDILTVNISVDMQLYATYPEKPPIPIFQIKAVSRLPVEGKLNTLHTIGRLIRASGVLRALWLKTEGAITMVCTRQRCRLNALLPANTYYSLAGPLGVNPLLAEKKKHIKKNTVSRGRGKMY
    

Molecular Weight43636.16 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)11.23

Net Charge (pH 7.4) 10.37

Charge Density (pH 7.0) 0.0284

GRAVY Index0.04

Hydrophobic Moment 0.79

Boman Index0.12

Instability Index35.84

Aliphatic Index 102.10

Aromaticity 0.0833

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47245.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0381589 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptobrachium leishanense [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence