Peptide Database

Peptide NameCirculin F

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC131H212N36O37S6

DescriptionStandard

        KVCYRAIPCGESCVWIPCISAAIGCSCKN
    

Molecular Weight3075.69 Da

Isoelectric Point (pI)8.33

Net Charge (pH 7.0)1.70

Net Charge (pH 7.4) 1.40

Charge Density (pH 7.0) 0.0586

GRAVY Index0.65

Hydrophobic Moment 0.49

Boman Index0.21

Instability Index17.63

Aliphatic Index 84.14

Aromaticity 0.0690

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1151.58

LogP -11.71

H-bond Donors 46.0

H-bond Acceptors 45.0

Rotatable Bonds 95.0

Heavy Atoms 210.0

Ring Count 5.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0371872 VERIFIED: YES

Provenance & Taxonomy

OrganismChassalia parviflora [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermCyclization

Disulfide4-20; 8-22; 13-27

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells

Activity0.05-0.275 μM

MethodEC50

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