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MYP_021470
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Basic Information
Circulin F
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Standard
29 amino acids
C131H212N36O37S6
Standard
Sequence
KVCYRAIPCGESCVWIPCISAAIGCSCKN
Physicochemical Analysis
3075.69 Da
8.33
1.70
1.40
0.0586
0.65
0.49
0.21
17.63
84.14
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1151.58
-11.71
46.0
45.0
95.0
210.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213108 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
NOTE: EC50 = concentration that is 50% effective
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0264932 VERIFIED: YES
Provenance & Taxonomy
Chassalia kolly [Plant]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0283342 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
50-275
EC50
PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0323793 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 24.1%, E 20.7%, T 24.1%, C 31.0% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0363194 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
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