Peptide Database

Peptide NameSLAY-screened peptide P5156

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC70H97N13O17S

DescriptionStandard

        TGTIVNYFFIFC
    

Molecular Weight1424.66 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-0.61

Net Charge (pH 7.4) -0.82

Charge Density (pH 7.0) -0.0511

GRAVY Index1.46

Hydrophobic Moment 0.24

Boman Index0.63

Instability Index-12.06

Aliphatic Index 89.17

Aromaticity 0.3333

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 487.20

LogP -1.65

H-bond Donors 18.0

H-bond Acceptors 18.0

Rotatable Bonds 41.0

Heavy Atoms 101.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0083557 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/