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MYP_021427
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C156H234N46O46S7
Standard
Sequence
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
Physicochemical Analysis
3714.26 Da
8.35
1.91
1.53
0.0597
0.00
0.37
-0.00
75.96
36.56
0.1562
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1491.17
-17.92
62.0
57.0
115.0
255.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186506 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31, 6-20, 10-30
Disulfide bonds between Cys4 and Cys31,Cys6 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | HEK293T-hACE2 cells
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. | Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL. | Viruses. 2021 Jun 26;13(7):1246. | DOI:10.3390/v13071246 | PMID:34206990 PMID34206990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0193908 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31; 6-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
equivalent to conventional 50% lethal doses (LD50s)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 8417977 | PubMed PMID: 17088326 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;8417977;17088326;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0233628 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31; 6-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
coli ATCC 25922 (vLD50=103±14 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 8417977 | PubMed PMID: 17088326 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;8417977;17088326;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0275247 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-20; 6-30; 10-31
Bio-Activity Profile
Antimicrobial
PMID24165598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24165598/
RECORD: Rec_0296440 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli MG1655
10 μM
MBC
PMID28423004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423004/
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