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MYP_021427
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C156H234N46O46S7
Standard
Sequence
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
Physicochemical Analysis
3714.26 Da
8.35
1.91
1.53
0.0597
0.00
0.37
-0.00
75.96
36.56
0.1562
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1491.17
-17.92
62.0
57.0
115.0
255.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0059466 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
constitutively: Constitutively expressed. AMP significance and human disease: A reduced expression is observed in ileal Crohn's disease (Wehkamp J et al., 2005). Chemical modification: Three disulfide bridges
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
PaperDefensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.
RECORD: Rec_0079027 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31; 6-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
(Ref.3)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 8417977 | PubMed PMID: 17088326 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;8417977;17088326;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0082698 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31; 6-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
NOTE: vLD50
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 8417977 | PubMed PMID: 17088326 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;8417977;17088326;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0129286 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-31; 6-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
Staphylococcus aureus ATCC 25923 (vLD50>256 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 8417977 | PubMed PMID: 17088326 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;8417977;17088326;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0159194 VERIFIED: YES
Provenance & Taxonomy
Pan troglodytes [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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