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MYP_021371
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Basic Information
Apelin-36
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Receptor/ligand interaction
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
36 amino acids
C185H298N68O42S
Standard
Sequence
LVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
Physicochemical Analysis
4178.84 Da
12.00
9.85
9.59
0.2735
-1.51
0.72
-0.44
83.47
29.72
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1781.73
-19.48
63.0
54.0
131.0
296.0
12.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0279606 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Apelin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
24:Pyrrolidone carboxylic acid
Bio-Activity Profile
Hormone Endocrine Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory
response to T-cell receptor
Mammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Apelin-36 (Bos taurus): PMID 9792798 PMID9792798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9792798/
RECORD: Rec_0300743 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Apelin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
NP-2/CD4
0.3 μg/mL
IC50
PaperApelin peptides block the entry of human immunodeficiency virus (HIV). PMID10802050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
RECORD: Rec_0369970 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
PMID10802050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
RECORD: Rec_0379569 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 infection
0.3 μg/mL
IC50
PaperApelin peptides block the entry of human immunodeficiency virus (HIV)
RECORD: Rec_0419182 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Cell-Cell Communication Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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