‹ ›
MYP_021371
← PREVIOUS NEXT → BACK
Basic Information
Apelin-36
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Receptor/ligand interaction
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
36 amino acids
C185H298N68O42S
Standard
Sequence
LVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
Physicochemical Analysis
4178.84 Da
12.00
9.85
9.59
0.2735
-1.51
0.72
-0.44
83.47
29.72
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1781.73
-19.48
63.0
54.0
131.0
296.0
12.0
38.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0020648 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of HIV-1 infection in CD4 APJ cells
7 μM
IC50
PaperPubMed PMID: 10802050; PubMed PMID: 11090199 PMID10802050;11090199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
RECORD: Rec_0038212 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Apelin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Gln24 Pyroglutamylation
Bio-Activity Profile
Neuropeptide Hormone
Evidence URLhttps://www.uniprot.org/uniprotkb/APEL_BOVIN/entry
RECORD: Rec_0064123 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0070860 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 | APJ cells
7 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperApelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. | Cayabyab M, Hinuma S, Farzan M, Choe H, Fukusumi S, Kitada C, Nishizawa N, Hosoya M, Nishimura O, Messele T, Pollakis G, Goudsmit J, Fujino M, Sodroski J. | J Virol. 2000 Dec;74(24):11972-6. | DOI:10.1128/jvi.74.24.11972-11976.2000 | PMID:11090199 PMID11090199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11090199/
RECORD: Rec_0083368 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Receptor Ligand
1 2 3 NEXT LAST
Showing 5 records on this page · Page 1 of 3