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MYP_021295
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Basic Information
Gamma-1-purothionin
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
47 amino acids
C212H347N77O61S9
Standard
Sequence
KICRRRSAGFKGPCMSNKNCAQVCQQEGWGGGNCDGPFRRCKCIRQC
Physicochemical Analysis
5239.09 Da
9.49
7.68
7.35
0.1634
-0.81
0.45
-0.30
86.92
27.02
0.0638
5500.00
6000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2292.30
-31.57
88.0
78.0
178.0
359.0
6.0
53.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134323 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Defensin
4565
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Protein Synthesis Inhibitor Cytotoxic
PaperPubMed PMID 2226781 | PubMed PMID 8380707 PMID2226781;8380707;22267818;380707 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0143999 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Defensin; Thionin
4565
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Antifungal Non-hemolytic
PMID2226781;8380707 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0181663 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Defensin
4565
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antifungal
PaperPubMed PMID: 2226781 | PubMed PMID: 8380707 PMID2226781;8380707 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0217220 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.3%, E 36.2%, T 23.4%, C 19.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0226210 VERIFIED: NO
Provenance & Taxonomy
Triticum aestivum [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-47; 14-34; 20-41; 24-43
Bio-Activity Profile
Protein Synthesis Inhibitor
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