Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length417 amino acids

Chemical FormulaC2056H3245N583O568S12

DescriptionStandard

        MWLCLLLLLPACVPTTASSPGIKGRVTRSALEYGRRFGLELLRSLLQKEHSVNLQGSYRAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRAQIQLNATWRAQLGVWQDSGSVQLHIGDLAVAVLLGLGADEHGHPSMWAAGCDAHGTDLHLEFHQGQSWLYNLLVPLLQRTLRQQLNKQLCVEIQKGISRLQGSLKNVRGGELGQWGWGSVPAQPSLLQLQQHFPNRPVELHLWARRQPLLSCHPKALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTIAGNRLGGTVGLKSLSVVQVRSHVGPLQVSGGDGTTMGYWGGEVTTPCTGPESKVPSGFTGILQVEKLENMLKFGLWLFGVPWANKQLRPGVPLPTPHGITLLHPRLSLHEGFMLIATDLHYEP
    

Molecular Weight45603.10 Da

Isoelectric Point (pI)8.91

Net Charge (pH 7.0)6.14

Net Charge (pH 7.4) 4.81

Charge Density (pH 7.0) 0.0147

GRAVY Index-0.03

Hydrophobic Moment 0.79

Boman Index0.12

Instability Index45.57

Aliphatic Index 102.37

Aromaticity 0.0671

Extinction Coeff. Reduced 69440.00

Extinction Coeff. Oxidized 69815.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413039 VERIFIED: NO

Provenance & Taxonomy

OrganismCallipepla squamata [Animal]

FamilyBPI

Tax ID9009

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence