Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length435 amino acids

Chemical FormulaC2153H3404N576O601S9

DescriptionStandard

        VYPGFVVRITQAGLDYARQHGVAILEQELHQLRLPDISGDFRVRRVGKVHYELSSLNLRSFRLPSSQISPIPNVGLQVSISDAFAVVDGNWRVKLHFIRDHGSFDLKVEDLSIRINLKLGSDGSGKPTADVSDCSAHVSSVRVHFSGKFSWLYNLFHSAVESVFRRTLESKVCEQVVSSVRGELQSYLRTLPVTAKIDAVAGIDYSLVAPPVAVAQALDADLKGEFFSLAHRSAVPFSPPPLAIPPDHARMVYFGASSYFFNTAGLVYHAAGALVFELTDSMIPKGLDFHLNTSTFSAFVPQLEKMYPDMLMKLRLSTPAAPFLSIGPEGLSLRPVVDIQAYAILPSASLAPLFLLNLVSGAQLVVPAAAATLGASVLTLPPCPVLPQVRTLQSVMNILASSILLPRLNARLAQGFPLPLLDRVQLSNVLVQSHQ
    

Molecular Weight47262.14 Da

Isoelectric Point (pI)8.69

Net Charge (pH 7.0)3.87

Net Charge (pH 7.4) 2.89

Charge Density (pH 7.0) 0.0089

GRAVY Index0.27

Hydrophobic Moment 0.70

Boman Index0.16

Instability Index42.62

Aliphatic Index 109.36

Aromaticity 0.0828

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27515.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0195261 VERIFIED: NO

Provenance & Taxonomy

OrganismNothocercus nigrocapillus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria