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MYP_021154
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Basic Information
Curvacin A (Bacteriocin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
41 amino acids
C184H288N56O56S4
Standard
Sequence
ARSYGNGVYCNNKKCWVNRGEATQSIIGGMISGWASGLAGM
Physicochemical Analysis
4308.86 Da
9.31
2.77
2.55
0.0677
-0.19
0.34
0.10
27.63
61.95
0.0976
13980.00
14105.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1829.10
-23.11
67.0
63.0
142.0
300.0
6.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0302908 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sakei [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0312203 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus curvatus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria ivanovvi
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1829
RECORD: Rec_0319816 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0330696 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sakei [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria monocytogenes
PMID1487735 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1487735/
RECORD: Rec_0337921 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus curvatus [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Carnobacterium sp and Brocothrix thermosphacta
PaperPubMed PMID: 7694558 | PubMed PMID: 16331975 PMID7694558;16331975 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7694558/
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