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MYP_021108
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Basic Information
Bombolitin II
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
17 amino acids
C83H148N22O22
Standard
Sequence
SKITDILAKLGKVLAHV
Physicochemical Analysis
1806.20 Da
9.70
1.55
1.28
0.0909
0.71
0.68
0.22
-4.23
160.59
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
713.42
-4.43
25.0
25.0
63.0
127.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125355 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0173714 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Hemolytic
guinea pig erythrocytes
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0301623 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0321703 VERIFIED: YES
Provenance & Taxonomy
American common bumblebee [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Toxicity
the peptide is highly hemolytic to pig RBC erythrocyte
3.9 μg/mL
ED50
PaperBombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.
RECORD: Rec_0371056 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Hemolytic activity
3.9±0.06 μg/mL
Hemolysis
PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
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