Peptide Database

Peptide Nameomega-Agatoxin IVB

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length48 amino acids

Chemical FormulaC218H351N65O70S9

DescriptionStandard

        EDNCIAEDYGKCTWGGTKCCRGRPLRCSMIGTNCECTPRLIMEGLSFA
    

Molecular Weight5291.10 Da

Isoelectric Point (pI)6.36

Net Charge (pH 7.0)-0.22

Net Charge (pH 7.4) -0.51

Charge Density (pH 7.0) -0.0047

GRAVY Index-0.28

Hydrophobic Moment 0.52

Boman Index-0.06

Instability Index31.11

Aliphatic Index 52.92

Aromaticity 0.0625

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2180.46

LogP -25.79

H-bond Donors 84.0

H-bond Acceptors 79.0

Rotatable Bonds 174.0

Heavy Atoms 362.0

Ring Count 6.0

Amide Bonds 49.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0000318 VERIFIED: YES

Provenance & Taxonomy

OrganismAgelenopsis aperta [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-20, 12-25, 19-36, 27-34

Bio-Activity Profile

Function

Toxin P-type calcium channel blocker

TargetP-type calcium channels in rat cerebellar Purkinje neurons

Activity~3 nM

MethodCalcium channel blocking assay (Kd)