Peptide Database

Peptide NameCholecystokinin

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC460H734N150O143S3

DescriptionStandard

        QPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
    

Molecular Weight10749.86 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)2.95

Net Charge (pH 7.4) 2.62

Charge Density (pH 7.0) 0.0311

GRAVY Index-1.02

Hydrophobic Moment 0.74

Boman Index-0.27

Instability Index80.47

Aliphatic Index 60.74

Aromaticity 0.0632

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4776.92

LogP -56.34

H-bond Donors 167.0

H-bond Acceptors 151.0

Rotatable Bonds 354.0

Heavy Atoms 756.0

Ring Count 17.0

Amide Bonds 103.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0155316 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGastrin/cholecystokinin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr77 Sulfotyrosine; Phe83 Amidation; Tyr91 Sulfotyrosine; Tyr93 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0419307 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyCholecystokinin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods77:Sulfotyrosine; 83:Phenylalanine amide; 91:Sulfotyrosine; 93:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour