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MYP_020875
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Basic Information
Unnamed
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
8 amino acids
C51H77N9O9
Standard
Sequence
IGFLIIWV
Physicochemical Analysis
960.21 Da
5.53
-0.24
-0.44
-0.0300
2.88
0.17
1.09
-1.86
231.25
0.2500
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
282.81
3.23
10.0
9.0
28.0
69.0
3.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0235128 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
HepG2 cells (H2O2-induced oxidative stress)
23.2 %
Intracellular ROS reduction assay
PaperBollati C., Cruz-Chamorro I., Aiello G., Li J., Bartolomei M., Santos-S¨¢nchez G., Ranaldi G., Ferruzza S., Sambuy Y., Arnoldi A., Lammi C.. Investigation of the intestinal trans-epithelial transport and antioxidant activity of two hempseed peptides WVSPLAGRT (H2) and IGFLIIWV (H3). Food Res. Int., 110720, 2021. PMID35181114
RECORD: Rec_0276177 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
3483.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory
LPS-stimulated HepG2 cells
20.3±1.7 %
TNF production reduction assay
PaperCruz-Chamorro I., Santos-S¨¢nchez G., Bollati C., Bartolomei M., Li J., Arnoldi A., Lammi C.. Hempseed (Cannabis sativa) peptides WVSPLAGRT and IGFLIIWV exert anti-inflammatory activity in the LPS-stimulated human hepatic cell line. J. Agric. Food Chem., 70, 577-583, 2022. PMID35007086
RECORD: Rec_0432441 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
HepG2 cells (H2O2-induced oxidative stress)
44 %
Lipid peroxidation reduction assay
PaperInvestigation of the intestinal trans-epithelial transport and antioxidant activity of two hempseed peptides WVSPLAGRT (H2) and IGFLIIWV (H3). PMID35181114
RECORD: Rec_0432442 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory Immunomodulatory
LPS-stimulated HepG2 cells
13.1±2.0 %
IFN-γ production reduction assay
PaperHempseed (Cannabis sativa) Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line. PMID35007086
RECORD: Rec_0432443 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory Immunomodulatory
LPS-stimulated HepG2 cells
15.1±6.5 %
IL-6 production reduction assay
PaperHempseed (Cannabis sativa) Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line. PMID35007086
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