Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length445 amino acids

Chemical FormulaC2253H3490N552O657S16

DescriptionStandard

        MYTKTIPVLWGCFLLWNLCLSSSQTIYPGIKARITQRALDYGVQAGMEIIERMLKEKNLPDLSGSESLEFLKVDYVNYNFSNIKIKAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLADPPFSPVPFVLPERSNSMLYIGITEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPVINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNGFLLISTDLKYETSSKQQPSFHGWEGLNLVSGQWRGKSAP
    

Molecular Weight49334.15 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-9.98

Net Charge (pH 7.4) -10.68

Charge Density (pH 7.0) -0.0224

GRAVY Index0.14

Hydrophobic Moment 0.71

Boman Index0.18

Instability Index33.19

Aliphatic Index 99.24

Aromaticity 0.1101

Extinction Coeff. Reduced 52830.00

Extinction Coeff. Oxidized 53080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0219242 VERIFIED: NO

Provenance & Taxonomy

OrganismRhinopithecus roxellana [Animal]

FamilyBPI

Tax ID61622

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence