Peptide Database

Peptide NameConotoxin Cl14.2b

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC70H114N26O24S4

DescriptionStandard

        RECPPRCPTSHCNAGTC
    

Molecular Weight1832.07 Da

Isoelectric Point (pI)7.90

Net Charge (pH 7.0)0.81

Net Charge (pH 7.4) 0.50

Charge Density (pH 7.0) 0.0477

GRAVY Index-0.87

Hydrophobic Moment 0.35

Boman Index-0.27

Instability Index59.82

Aliphatic Index 5.88

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 796.11

LogP -12.97

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 52.0

Heavy Atoms 124.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0211912 VERIFIED: NO

Provenance & Taxonomy

OrganismConus californica [Animal]

FamilyConotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0432433 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyConotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Calcium-channel modulator CaV1.2/CaV1.3 current enhancer Insulin secretion

Targetrat pancreatic beta-cell CaV1.2/CaV1.3 channels

Activity35±4 %

Methodwhole-cell patch-clamp Ca2+ current increase