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MYP_020659
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Basic Information
peptide 9
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
24 amino acids
C144H254N58O27
Standard
Sequence
IIRILQQLLFIHFRIGRRRRRRRR
Physicochemical Analysis
3229.93 Da
12.00
9.85
9.59
0.4103
-0.67
0.59
-0.60
207.10
130.00
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1466.48
-10.84
58.0
38.0
115.0
229.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015262 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0075807 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Integrase inhibition
inhibition of strand transfer catalyzed by integrase
0.07±0.01 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0183914 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
0.11±0.01 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. | Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H. | Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. | DOI:10.1016/j.bmc.2010.07.050 | PMID:20708407 PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0323724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
0.11±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/
RECORD: Rec_0383241 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
0.07±0.01 μM
IC50
PaperPeptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies PMID20708407 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708407/