Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length624 amino acids

Chemical FormulaC3074H4838N834O869S18

DescriptionStandard

        MPGSPPRPRGFGGSGGQNMAREPDKALTRATLVVLATLGTAVIATTNPGVVARITQKGLDYACQQGVAVLQKELEKITIPTFSGSFKIKHLGKGHYSFHSMAIRGFQLPVSQIKLAPSEGLDLSIANANVKISGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCNNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTGEICKVVTSSVSSKLQRYLETMPVTTRIDHVAGINYSLVAPPTATTDSLDGQLKGEFFRWGHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGILIPQVAKMFPNMKVQLVFWASSPPHLTVHPEGLVLTPTLDAQAFAVLPNSSLAPLFVLRLSMNISVTVGATPDRLVGQLSLNSPPAVSTESPAPWTAPPSWADAWLGDASWCLQPALSHGSAQPPASLIRLSARKTHSDFLLPHPWDFVSRLVLEEPQQRRLWLSAGSGVEAARPQSAAHLANTELTKVLLPWLQKRPSDLEETNKLLLELKHSDIGPFSVEVLQALMNYVVPIAVIPKVNERLQEGFPLPMPNNVQLFNLVLQSHQNFLLFGADVRYG
    

Molecular Weight67959.53 Da

Isoelectric Point (pI)9.29

Net Charge (pH 7.0)12.06

Net Charge (pH 7.4) 10.74

Charge Density (pH 7.0) 0.0193

GRAVY Index-0.01

Hydrophobic Moment 0.71

Boman Index0.11

Instability Index45.13

Aliphatic Index 93.43

Aromaticity 0.0785

Extinction Coeff. Reduced 73910.00

Extinction Coeff. Oxidized 74285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0275619 VERIFIED: NO

Provenance & Taxonomy

OrganismFelis catus [Animal]

FamilyBPI

Tax ID9685

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence