Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2285H3600N572O672S20

DescriptionStandard

        MWKSLLLLLAIAQRALGAFGANPGVKAMLTSKGLEYGKHVGANLLQEKLGALSIPAVQGDISISPFGSVHFSLDSMQVSKFNLPEPTVEFSEGSGIKTGLAGMNIAVHGNWHTSYQFIKDGGTFDLAVYGVGISLLLSLGSDEAGHLSVSSSMCDSTVGSTDVSFHGGASFIFSLFIGEIRRVIQQKIETSICPMITQSVDGLERHLQEMNVSFQIDPYVLIEIPLLSAPLVGNSDMELDLKGEFYSTRGHPEPPFPAGAFSLAAQEGRMLALGLSEFFFNSAAFAYMAAGLLQVNLTDSMLPKTSPVHLNTSSFGAFVPQLPKMFPNMLMTVQAFASKPPVVSLQPDNVTMGLSGAAKVFAILPNSSLAPLFTLESEASLDAKVFISDMKLTGSLALRSLTLTLAASEVGEFQTTPLENLLKMGVQTVVLPKVNEKLKAGFPIPPIYNISCVDPVLKVNQGFVTIATDAQYSS
    

Molecular Weight50477.75 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-10.69

Net Charge (pH 7.4) -11.50

Charge Density (pH 7.0) -0.0226

GRAVY Index0.29

Hydrophobic Moment 0.74

Boman Index0.23

Instability Index35.30

Aliphatic Index 98.97

Aromaticity 0.0823

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254390 VERIFIED: NO

Provenance & Taxonomy

OrganismAtractosteus spatula [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence