Peptide Database

Peptide NameK8I,W9F,T14A (mutant of Def-DAA defensin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC183H286N60O50S6

DescriptionStandard

        ATCDLASIFNWNHALCAAHCIARRYRGGYCNSKAVCVCR
    

Molecular Weight4318.99 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)3.91

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1002

GRAVY Index0.17

Hydrophobic Moment 0.52

Boman Index0.01

Instability Index18.31

Aliphatic Index 72.82

Aromaticity 0.1026

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1783.61

LogP -20.26

H-bond Donors 71.0

H-bond Acceptors 62.0

Rotatable Bonds 136.0

Heavy Atoms 299.0

Ring Count 7.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239645 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus strain 4

Activity2-4 μg/mL

MethodIC90

RECORD: Rec_0287162 VERIFIED: YES