Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length446 amino acids

Chemical FormulaC2205H3467N589O626S16

DescriptionStandard

        MARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESSIRKTMNNKVGHAQSPGNGGGGEWRDVSVCVLLDPSALTPESSQLTGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLVTSSSPSHRLLLELKHSDVGSFSVSLRTDLPSIAERLQEGFPLPMPKNVQLFNLVLQTHQDFLLFGADVHYSG
    

Molecular Weight48756.73 Da

Isoelectric Point (pI)9.23

Net Charge (pH 7.0)8.79

Net Charge (pH 7.4) 7.68

Charge Density (pH 7.0) 0.0197

GRAVY Index0.02

Hydrophobic Moment 0.70

Boman Index0.13

Instability Index40.77

Aliphatic Index 93.12

Aromaticity 0.0852

Extinction Coeff. Reduced 39420.00

Extinction Coeff. Oxidized 39670.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0146613 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus dingo [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria