‹ ›
MYP_020411
← PREVIOUS NEXT → BACK
Basic Information
BPIP
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C86H138N22O25S
Standard
Sequence
LLMVNEATRFQTVSGFV
Physicochemical Analysis
1912.21 Da
6.00
-0.24
-0.44
-0.0139
0.70
0.40
0.25
9.41
102.94
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
774.99
-6.87
27.0
26.0
62.0
134.0
2.0
18.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0095880 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2: inhibition of Mpro
0.00052 μM
IC50
PaperPubMed PMID: 35896605 PMID35896605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35896605/
RECORD: Rec_0157402 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 35896605 PMID35896605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35896605/
RECORD: Rec_0233000 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 35896605 PMID35896605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35896605/
RECORD: Rec_0389210 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2
0.00052 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperA ricin-based peptide BRIP from Hordeum vulgare inhibits Mpro of SARS-CoV-2 | Kashyap P, Bhardwaj VK, Chauhan M, Chauhan V, Kumar A, Purohit R, Kumar A, Kumar S | Sci Rep. 2022 Jul 27;12(1):12802 | DOI:10.1038/s41598-022-15977-y | PMID:35896605 PMID35896605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35896605/