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MYP_020401
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Basic Information
peptide 11
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKXWKKWWK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160708 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X=Bip (Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7/mdr
8.4±2.7 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0196948 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0224943 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
X=D-Bip (D-Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0241379 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: AT84
36.7±9.5 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0250526 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
X=D-Bip (D-Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
A20
8.3±1.5 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
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