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MYP_020401
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Basic Information
peptide 11
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKXWKKWWK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071139 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Bip (Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
151±16 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0073404 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
K562/Gleevec
7.9±2.9 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0095596 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Bip (Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
AT84
17.7±3.1 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0102348 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
X=D-Bip (D-Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: AT84
11.3±1.2 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0112641 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
IGROV-1
13.4±1.6 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
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