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MYP_020298
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Basic Information
TsAP-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C84H136N18O19S
Standard
Sequence
FLGMIPGLIGGLISAFK
Physicochemical Analysis
1734.15 Da
8.75
0.76
0.55
0.0447
1.55
0.36
0.67
6.14
143.53
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
566.38
-1.16
19.0
21.0
56.0
122.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0273773 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Brazilian yellow scorpion [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Candida albicans SC5314
10-50 μM
MIC
PaperTwo peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
RECORD: Rec_0284134 VERIFIED: YES
Provenance & Taxonomy
T. costatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Antifungal
C. neoformans B3501 serotype D
12.5 μM
MIC
PMID27917162 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27917162/
RECORD: Rec_0306615 VERIFIED: YES
Provenance & Taxonomy
T. costatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Exhibits hemolysis against Human RBC
Hemolysis
PMID27917162 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27917162/
RECORD: Rec_0323850 VERIFIED: YES
Provenance & Taxonomy
Tityus serrulatus [Animal]
Venom-derived cDNot Available library of the Brazilian yellow scorpion, Tityus serrulatus
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
13.3 μM
IC50
PMID23770440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23770440/
RECORD: Rec_0327756 VERIFIED: YES
Provenance & Taxonomy
Tityus serrulatus [Animal]
Venom-derived cDNot Available library of the Brazilian yellow scorpion, Tityus serrulatus
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
HI-57
4.1 μM
IC50
PMID23770440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23770440/
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