‹ ›
MYP_020298
← PREVIOUS NEXT → BACK
Basic Information
TsAP-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C84H136N18O19S
Standard
Sequence
FLGMIPGLIGGLISAFK
Physicochemical Analysis
1734.15 Da
8.75
0.76
0.55
0.0447
1.55
0.36
0.67
6.14
143.53
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
566.38
-1.16
19.0
21.0
56.0
122.0
3.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0018683 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Brazilian yellow scorpion [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli
>320 μM
MIC
PaperTwo peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
RECORD: Rec_0023406 VERIFIED: YES
Provenance & Taxonomy
Tityus serrulatus [Animal]
Venom-derived cDNot Available library of the Brazilian yellow scorpion, Tityus serrulatus
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
6.4 μM
IC50
PMID23770440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23770440/
RECORD: Rec_0024940 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Brazilian yellow scorpion [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Cryptococcus neoformans B3501 serotype D
12.5 μM
MIC
PaperTwo peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
RECORD: Rec_0069647 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0092451 VERIFIED: YES
Provenance & Taxonomy
Brazilian yellow [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23770440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23770440/
1 2 3 ... 7 NEXT LAST
Showing 5 records on this page · Page 1 of 7