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MYP_020292
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Basic Information
peptide 4bb[F505A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EKIXQSLXAIXKSDXLLHNV
Physicochemical Analysis
0.00 Da
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0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
None
The 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling.
Bio-Activity Profile
Antiviral Anti-RSV Fusion inhibition
Respiratory syncytial virus (RSV) | Hep-2 cells
1.39±0.1 μM
EC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperA Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading. | Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O. | Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16. | DOI:10.1128/AAC.02241-16 | PMID:28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0028226 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 4,8,11,15
Bio-Activity Profile
Antiviral
Respiratory syncytial virus (RSV)
PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0110325 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
None
The 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
Respiratory syncytial virus (RSV):inhibition of virus infection in Hep-2 cells
1.39±0.1 μM
EC50
PaperPubMed PMID: 28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/
RECORD: Rec_0364852 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
None
The 'X' at position 4,8,11,15 indicates S-pentenylalanine, X(4) and X(8), X(11) and X(15) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 28137809 PMID28137809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28137809/