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MYP_020204
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Basic Information
HP23-E6-IDL
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C182H288N44O59S
Standard
Sequence
EMTWEEWEKKIEEYTKKIEEILKKSQNQQIDL
Physicochemical Analysis
4068.56 Da
4.73
-3.15
-3.34
-0.0984
-1.46
0.68
-0.29
68.53
73.12
0.0938
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1742.10
-11.55
58.0
57.0
148.0
286.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226877 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Acute myeloid leukemia AML-M7
PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0237397 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0253579 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0260149 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human T cell leukemia MT-2
PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
RECORD: Rec_0261967 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1Bal (R5 virus) | MT-2 cells
0.000813 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperA Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life. | Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S. | Molecules. 2019 Mar 21;24(6):1134. | DOI:10.3390/molecules24061134 | PMID:30901967 PMID30901967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30901967/
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