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MYP_020164
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Basic Information
Conotoxin Lt14a
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XCPPMCNPGCENCS
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188655 VERIFIED: YES
Provenance & Taxonomy
Conus litteratus [Animal]
Conotoxin
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Pyroglutamylation
Amidation
Bio-Activity Profile
nAChR antagonist Analgesic Toxin
neuronal nicotinic acetylcholine receptors (nAChRs); PC12 cells
whole-cell patch-clamp nAChR inhibition assay
PaperDiscovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern; Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. PMID16797781;21126549;25617597
RECORD: Rec_0432411 VERIFIED: YES
Provenance & Taxonomy
Conus litteratus [Animal]
Conotoxin
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Pyroglutamylation
Amidation
Disulfide bond(s) reported, sites unresolved
Bio-Activity Profile
Analgesic Toxin
mice (hot-plate pain model)
hot-plate antinociception assay
PaperStructure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. PMID21126549