Peptide Database

Peptide NameSLAY-screened peptide P2786

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H154N28O34S2

DescriptionStandard

        LCPTSTVDRHYDYNVPMWNE
    

Molecular Weight2440.66 Da

Isoelectric Point (pI)4.81

Net Charge (pH 7.0)-2.15

Net Charge (pH 7.4) -2.43

Charge Density (pH 7.0) -0.1077

GRAVY Index-0.88

Hydrophobic Moment 0.40

Boman Index-0.08

Instability Index63.31

Aliphatic Index 48.50

Aromaticity 0.1500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1004.24

LogP -9.17

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 71.0

Heavy Atoms 171.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335630 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/