Peptide Database

Peptide NameSLAY-screened peptide P4344

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC94H158N38O29S2

DescriptionStandard

        CNRGRRSGTYSIRESHRCPL
    

Molecular Weight2348.63 Da

Isoelectric Point (pI)10.66

Net Charge (pH 7.0)3.83

Net Charge (pH 7.4) 3.54

Charge Density (pH 7.0) 0.1915

GRAVY Index-1.31

Hydrophobic Moment 0.63

Boman Index-0.54

Instability Index70.88

Aliphatic Index 39.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1127.15

LogP -16.34

H-bond Donors 45.0

H-bond Acceptors 36.0

Rotatable Bonds 77.0

Heavy Atoms 163.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0137409 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/