Peptide Database

Peptide NameNaD2 (1-7) - NaD1 (8-47)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC220H368N68O65S8

DescriptionStandard

        RTCESQSNTFPGICITKPPCRKACISEKFTDGHCSKILRRCLCTKPC
    

Molecular Weight5262.21 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)5.77

Net Charge (pH 7.4) 5.39

Charge Density (pH 7.0) 0.1228

GRAVY Index-0.41

Hydrophobic Moment 0.63

Boman Index-0.18

Instability Index71.18

Aliphatic Index 51.91

Aromaticity 0.0426

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2153.29

LogP -26.91

H-bond Donors 84.0

H-bond Acceptors 80.0

Rotatable Bonds 173.0

Heavy Atoms 361.0

Ring Count 7.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128795 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0266924 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0289212 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetHuman histiocytic lymphoma U-937 0-10% Killing

Activity10 μM

RECORD: Rec_0342415 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetFusarium oxysporum f.sp. vasinfectum

Activity3.2

MethodIC50

RECORD: Rec_0400344 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetU-937

Activity7.9±2.4 %

MethodCytotoxicity