Peptide Database

Peptide NamePentastatin-1

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H164N30O27S4

DescriptionStandard

        LRRFSTMPFMFCNINNVCNF
    

Molecular Weight2454.91 Da

Isoelectric Point (pI)9.02

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.51

Charge Density (pH 7.0) 0.0870

GRAVY Index0.32

Hydrophobic Moment 0.47

Boman Index0.09

Instability Index93.83

Aliphatic Index 53.50

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 944.05

LogP -8.40

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 77.0

Heavy Atoms 170.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0344959 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

PaperA systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13775-13780. doi: 10.1073/pnas.0803241105. PMID: 18780781. PMID18780781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/

RECORD: Rec_0402076 VERIFIED: YES