Peptide Database

Peptide NameSLAY-screened peptide P5109

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC84H113N23O26

DescriptionStandard

        PYSGHYFSIHAGASTHE
    

Molecular Weight1860.93 Da

Isoelectric Point (pI)6.30

Net Charge (pH 7.0)-0.77

Net Charge (pH 7.4) -0.99

Charge Density (pH 7.0) -0.0455

GRAVY Index-0.61

Hydrophobic Moment 0.07

Boman Index0.17

Instability Index37.52

Aliphatic Index 34.71

Aromaticity 0.1765

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 759.65

LogP -8.81

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 54.0

Heavy Atoms 133.0

Ring Count 7.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0135816 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/