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MYP_019952
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Basic Information
Pilosulin-1 (Myr b I; ants, insects, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
56 amino acids
C272H471N77O71S3
Standard
Sequence
GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ
Physicochemical Analysis
6052.32 Da
10.45
6.76
6.54
0.1208
-0.06
0.92
0.01
37.61
102.68
0.0179
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2375.75
-18.34
79.0
81.0
210.0
423.0
6.0
59.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022159 VERIFIED: YES
Provenance & Taxonomy
Myrmecia banksi [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Stenotrophomonas maltophilia O-16451
2 μM
MIC
PMID9813247;9701394;15639237;8866004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9813247/
RECORD: Rec_0028021 VERIFIED: YES
Provenance & Taxonomy
Myrmecia banksi [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
aureuss (MRSA) LT1338
3 μM
MIC
PMID9813247;9701394;15639237;8866004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9813247/
RECORD: Rec_0033653 VERIFIED: YES
Provenance & Taxonomy
Myrmecia banksi [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli O-19592
2 μM
MIC
PMID9813247;9701394;15639237;8866004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9813247/
RECORD: Rec_0052777 VERIFIED: YES
Provenance & Taxonomy
Myrmecia banksi [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa 4991
4 μM
MIC
PMID9813247;9701394;15639237;8866004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9813247/
RECORD: Rec_0058803 VERIFIED: YES
Provenance & Taxonomy
Myrmecia pilosula [Animal]
Pilosulin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic Anti-mammalian cells
PaperBiochim Biophys Acta. 1993 Jan 23;1171(3):272-80. | http://www.ncbi.nlm.nih.gov/pubmed/7678752 PMID7678752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7678752/
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